Design, synthesis and molecular docking of novel 4-chloro-2-(4-(4-(sulfonyl)piperazin-1-yl)phenyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one for the evaluation anti-cancer activity

Design, synthesis and molecular docking of novel 4-chloro-2-(4-(4-(sulfonyl)piperazin-1-yl)phenyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one for the evaluation anti-cancer activity

A series of novel 4-chloro-2-(4-(4-(sulfonyl)piperazin-1-yl)phenyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one derivatives (9a-n) were rationally designed, synthesized, and evaluated for their anticancer activity against MCF-7 and A-549 cancer cell lines. The synthesis followed a stepwise approach i...

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Bibliographic Details
Main Authors: Narender Reddy Modugu, Rajashekar Reddy Nimmareddy, Bhimcharan Maiti, Kavitha Siddoju
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Results in Chemistry
Subjects:
Anticancer
Piperazinyl-pyridinone derivatives
Molecular docking
MTT assay
EGFR tyrosine kinase
Estrogen receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715625002474
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