Genome analyses of amphotericin B-susceptible and -resistant strains of Leishmania (Mundinia) martiniquensis reveal variations potentially related to amphotericin B resistance

Genome analyses of amphotericin B-susceptible and -resistant strains of Leishmania (Mundinia) martiniquensis reveal variations potentially related to amphotericin B resistance

Amphotericin B deoxycholate (AmpB) is used for the treatment of leishmaniasis caused by Leishmania (Mundinia) martiniquensis in Thailand, and relapse cases have been documented. To date, genomic analysis of drug-resistant L. martiniquensis strains is limited. In this study, comparative genome analys...

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Main Authors: Narissara Jariyapan, Sivamoke Dissook, Pitiporn Noisagul, Patcharawadee Thongkumkoon, Chonlada Mano, Romteera Kittichaiworakul, Anuluck Junkum, Adisak Tantiworawit, Pascale Pescher, Gerald F. Späth, Hatim Almutairi, Padet Siriyasatien
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Current Research in Parasitology and Vector-Borne Diseases
Subjects:
Leishmania
Leishmania martiniquensis
Amphotericin B
Resistance
Ergosterol
Genome
Online Access:http://www.sciencedirect.com/science/article/pii/S2667114X25000159
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