Allelic expression mapping across cellular lineages to establish impact of non‐coding SNPs

Allelic expression mapping across cellular lineages to establish impact of non‐coding SNPs

Abstract Most complex disease‐associated genetic variants are located in non‐coding regions and are therefore thought to be regulatory in nature. Association mapping of differential allelic expression (AE) is a powerful method to identify SNPs with direct cis‐regulatory impact (cis‐rSNPs). We used A...

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Main Authors: Veronique Adoue, Alicia Schiavi, Nicholas Light, Jonas Carlsson Almlöf, Per Lundmark, Bing Ge, Tony Kwan, Maxime Caron, Lars Rönnblom, Chuan Wang, Shu‐Huang Chen, Alison H Goodall, Francois Cambien, Panos Deloukas, Willem H Ouwehand, Ann‐Christine Syvänen, Tomi Pastinen
Format: Article
Language:English
Published: Springer Nature 2014-10-01
Series:Molecular Systems Biology
Subjects:
allelic expression
cis‐rSNPs
complex disease
NFκB
repressor
Online Access:https://doi.org/10.15252/msb.20145114
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https://doi.org/10.15252/msb.20145114

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