Functions and regulation of the MRX complex at DNA double-strand breaks
DNA double-strand breaks (DSBs) pose a serious threat to genome stability and cell survival. Cells possess mechanisms that recognize DSBs and promote their repair through either homologous recombination (HR) or non-homologous end joining (NHEJ). The evolutionarily conserved Mre11-Rad50-Xrs2 (MRX) co...
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2016-07-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/functions-and-regulation-of-the-mrx-complex-at-dna-double-strand-breaks/ |
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| _version_ | 1850053161729916928 |
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| author | Elisa Gobbini Corinne Cassani Matteo Villa Diego Bonetti Maria Pia Longhese |
| author_facet | Elisa Gobbini Corinne Cassani Matteo Villa Diego Bonetti Maria Pia Longhese |
| author_sort | Elisa Gobbini |
| collection | DOAJ |
| description | DNA double-strand breaks (DSBs) pose a serious threat to genome stability and cell survival. Cells possess mechanisms that recognize DSBs and promote their repair through either homologous recombination (HR) or non-homologous end joining (NHEJ). The evolutionarily conserved Mre11-Rad50-Xrs2 (MRX) complex plays a central role in the cellular response to DSBs, as it is implicated in controlling end resection and in maintaining the DSB ends tethered to each other. Furthermore, it is responsible for DSB signaling by activating the checkpoint kinase Tel1 that, in turn, supports MRX function in a positive feedback loop. The present review focuses mainly on recent works in the budding yeast Saccharomyces cerevisiae to highlight structure and regulation of MRX as well as its interplays with Tel1. |
| format | Article |
| id | doaj-art-7af6982a4cdf4ca6a8e4c3703a3c080e |
| institution | DOAJ |
| issn | 2311-2638 |
| language | English |
| publishDate | 2016-07-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj-art-7af6982a4cdf4ca6a8e4c3703a3c080e2025-08-20T02:52:37ZengShared Science Publishers OGMicrobial Cell2311-26382016-07-013832933710.15698/mic2016.08.517Functions and regulation of the MRX complex at DNA double-strand breaksElisa Gobbini0Corinne Cassani1Matteo Villa2Diego Bonetti3Maria Pia Longhese4Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.Institute of Molecular Biology gGmbH (IMB), 55128 Mainz, Germany.Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.DNA double-strand breaks (DSBs) pose a serious threat to genome stability and cell survival. Cells possess mechanisms that recognize DSBs and promote their repair through either homologous recombination (HR) or non-homologous end joining (NHEJ). The evolutionarily conserved Mre11-Rad50-Xrs2 (MRX) complex plays a central role in the cellular response to DSBs, as it is implicated in controlling end resection and in maintaining the DSB ends tethered to each other. Furthermore, it is responsible for DSB signaling by activating the checkpoint kinase Tel1 that, in turn, supports MRX function in a positive feedback loop. The present review focuses mainly on recent works in the budding yeast Saccharomyces cerevisiae to highlight structure and regulation of MRX as well as its interplays with Tel1.http://microbialcell.com/researcharticles/functions-and-regulation-of-the-mrx-complex-at-dna-double-strand-breaks/ double-strand breakresectionMRXnucleasesTel1 Rif2Sae2 |
| spellingShingle | Elisa Gobbini Corinne Cassani Matteo Villa Diego Bonetti Maria Pia Longhese Functions and regulation of the MRX complex at DNA double-strand breaks Microbial Cell double-strand break resection MRX nucleases Tel1 Rif2 Sae2 |
| title | Functions and regulation of the MRX complex at DNA double-strand breaks |
| title_full | Functions and regulation of the MRX complex at DNA double-strand breaks |
| title_fullStr | Functions and regulation of the MRX complex at DNA double-strand breaks |
| title_full_unstemmed | Functions and regulation of the MRX complex at DNA double-strand breaks |
| title_short | Functions and regulation of the MRX complex at DNA double-strand breaks |
| title_sort | functions and regulation of the mrx complex at dna double strand breaks |
| topic | double-strand break resection MRX nucleases Tel1 Rif2 Sae2 |
| url | http://microbialcell.com/researcharticles/functions-and-regulation-of-the-mrx-complex-at-dna-double-strand-breaks/ |
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