Functions and regulation of the MRX complex at DNA double-strand breaks

Functions and regulation of the MRX complex at DNA double-strand breaks

DNA double-strand breaks (DSBs) pose a serious threat to genome stability and cell survival. Cells possess mechanisms that recognize DSBs and promote their repair through either homologous recombination (HR) or non-homologous end joining (NHEJ). The evolutionarily conserved Mre11-Rad50-Xrs2 (MRX) co...

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Bibliographic Details
Main Authors: Elisa Gobbini, Corinne Cassani, Matteo Villa, Diego Bonetti, Maria Pia Longhese
Format: Article
Language:English
Published: Shared Science Publishers OG 2016-07-01
Series:Microbial Cell
Subjects:
double-strand break
resection
MRX
nucleases
Tel1
Rif2
Sae2
Online Access:http://microbialcell.com/researcharticles/functions-and-regulation-of-the-mrx-complex-at-dna-double-strand-breaks/
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