Gene expression analysis of primary graft dysfunction in adult heart transplant recipients: A cohort study

Gene expression analysis of primary graft dysfunction in adult heart transplant recipients: A cohort study

Background: Cardiac transplantation remains the primary treatment for advanced heart failure, with primary graft dysfunction (PGD) being the leading cause of early mortality. While PGD’s exact pathogenesis is unclear, ischemia/reperfusion injury is a key factor. Donor hearts undergo multiple stresse...

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Main Authors: Samuel Padovani Steffen, MD, Alvaro Monteiro Perazzo, MD, MSc, Shirlyne Fabianni Dias Gaspar, MD, Ronaldo Honorato Barros Santos, MD, Domingos Dias Lourenço Filho, MD, PhD, Alexandre da Costa Pereira, MD, PhD, Luis Fernando B. da Costa Seguro, MD, PhD, Fabiana G. Marcondes-Braga, MD, PhD, Fernando Bacal, MD, PhD, Jose Eduardo Krieger, MD, PhD, Fabio Antonio Gaiotto, MD, PhD, Fabio Biscegli Jatene, MD, PhD
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:JHLT Open
Subjects:
heart transplantation
primary graft dysfunction
gene expression
transcriptomics
MYL4
Online Access:http://www.sciencedirect.com/science/article/pii/S2950133425000102
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