Overcoming temozolomide resistance in glioma: recent advances and mechanistic insights

Overcoming temozolomide resistance in glioma: recent advances and mechanistic insights

Abstract Temozolomide (TMZ) remains the cornerstone chemotherapy for glioma, yet intrinsic and acquired resistance mechanisms significantly limit its clinical effectiveness. This review summarizes the multifaceted molecular pathways contributing to TMZ resistance, including enhanced DNA repair mecha...

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Main Authors: Hengzeng Li, Yahui Wu, Yue Chen, Jinquan Lv, Chengkang Qu, Tingjie Mei, Yunfan Zheng, Cheng Ye, Feifei Li, Shuo Ge, Anhui Yao, Liyun Jia
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Acta Neuropathologica Communications
Subjects:
Temozolomide
Glioma
Chemoresistance
Treatment strategies
Online Access:https://doi.org/10.1186/s40478-025-02046-4
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https://doi.org/10.1186/s40478-025-02046-4

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