Development and validation of an LC–MS/MS method for quantitative determination of LXT-101 sustained-release suspension, a novel drug in treating prostate cancer, in beagle plasma

Development and validation of an LC–MS/MS method for quantitative determination of LXT-101 sustained-release suspension, a novel drug in treating prostate cancer, in beagle plasma

Abstract The pharmacokinetics of LXT-101 sustained-release suspension, an anti-prostate cancer polypeptide, were studied on beagle dogs using a high-performance liquid chromatography-tandem mass spectrometry (LC–MS/MS) method. Samples were prepared by the protein precipitation, evaporation and recon...

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Bibliographic Details
Main Authors: Jinglai Li, Lan Yin, Yuexin Li, Yutao Xue, Xiaoying Wang, Wenxia Xu, Zhenqing Zhang, Shan Xiong
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
LXT-101
Sustained-release suspension
Prostate cancer
LC–MS/MS
Pharmacokinetics
Beagle dogs
Online Access:https://doi.org/10.1038/s41598-025-96764-3
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https://doi.org/10.1038/s41598-025-96764-3

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