BCG-derived acellular membrane vesicles elicit antimycobacterial immunity and innate immune memory

BCG-derived acellular membrane vesicles elicit antimycobacterial immunity and innate immune memory

Tuberculosis (TB) is one of the leading causes of death due to infectious disease. The sole established vaccine against TB is the Mycobacterium bovis Bacillus Calmette–Guerin (BCG) vaccine. However, owing to the lack of durable immunity with the BCG vaccine and its risk of infection, safer vaccines...

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Bibliographic Details
Main Authors: Takehiro Yamaguchi, Noriaki Samukawa, Sohkichi Matsumoto, Masayuki Shiota, Masaki Matsumoto, Ryoma Nakao, Satoru Hirayama, Yutaka Yoshida, Akihito Nishiyama, Yuriko Ozeki, Shuhei Tomita
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
BCG
tuberculosis
acellular vaccines
membrane vesicles (MVs)
trained immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1534615/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1534615/full

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