2-aminoethoxydiphenylborane intervenes intracellular calcium signaling and attenuates myocardial ischemia-reperfusion injury in mice through ITPR1/MCU pathway

2-aminoethoxydiphenylborane intervenes intracellular calcium signaling and attenuates myocardial ischemia-reperfusion injury in mice through ITPR1/MCU pathway

Abstract Myocardial ischemia-reperfusion (MI/R) injury frequently occurs during the clinical management of ischemic heart disease. The underlying mechanism includes neutrophil infiltration, heightened intracellular Ca2+ levels, mitochondrial energy metabolism disorder. This study investigated the pa...

Full description

Saved in:
Bibliographic Details
Main Authors: Hailong Bao, Xin Chen, Xi Hu, Zhaoxing Cao, Wei Zhou, Bingxiu Chen, Fujun Liao, Fang Wei, Runze Huang, Wei Li, Zhangrong Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Myocardial ischemia-reperfusion
Inositol 1,4,5-trisphosphate receptor
Mitochondrial calcium uniporter
Mitochondria
2-aminoethoxydiphenylborane
Calcium overload
Online Access:https://doi.org/10.1038/s41598-025-14822-2
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-025-14822-2

Similar Items