Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium.

Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium.

The relative roles of the endosomal TLR3/7/8 versus the intracellular RNA helicases RIG-I and MDA5 in viral infection is much debated. We investigated the roles of each pattern recognition receptor in rhinovirus infection using primary bronchial epithelial cells. TLR3 was constitutively expressed; h...

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Main Authors: Louise Slater, Nathan W Bartlett, Jennifer J Haas, Jie Zhu, Simon D Message, Ross P Walton, Annemarie Sykes, Samer Dahdaleh, Deborah L Clarke, Maria G Belvisi, Onn M Kon, Takashi Fujita, Peter K Jeffery, Sebastian L Johnston, Michael R Edwards
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001178&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001178&type=printable

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