PLOD1 promotes the malignancy of hepatocellular carcinoma by facilitating the NF-κB/IL-6/STAT3-dependent TCA cycle

PLOD1 promotes the malignancy of hepatocellular carcinoma by facilitating the NF-κB/IL-6/STAT3-dependent TCA cycle

Background & Aims: Procollagen lysyl hydroxylase 1 (PLOD1) is crucial in regulating collagen synthesis and cross-linking. However, its roles and underlying mechanisms in the progression of hepatocellular carcinoma (HCC) remain unclear. Herein, we aimed to investigate the underlying biologica...

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Bibliographic Details
Main Authors: Chengfei Zhang, Yangchun Zhou, Minghua Hu, Yue Pan, Xin Chen, Qi Sun, Zhijie Ma, Cheng Wang, Yong Zha, Feng Zhu, Hongping Xia
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:JHEP Reports
Subjects:
PLOD1
HCC
NF-κB
STAT3
TCA cycle
Tumor stem cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555925000059
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