Immunomodulatory effects of cysteamine and its potential use as a host-directed therapy for tuberculosis

Immunomodulatory effects of cysteamine and its potential use as a host-directed therapy for tuberculosis

ObjectiveCysteamine, a drug approved to treat cystinosis, has been proposed as a host-directed therapy for M. tuberculosis (Mtb) and SARS-CoV-2. The impact of cysteamine on the immune responses has not been fully investigated. We aimed to in vitro evaluate the immunomodulatory effects of cysteamine...

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Main Authors: Saeid Najafi-Fard, Chiara Farroni, Linda Petrone, Anna Maria Gerarda Altera, Andrea Salmi, Valentina Vanini, Gilda Cuzzi, Tonino Alonzi, Emanuele Nicastri, Gina Gualano, Fabrizio Palmieri, Mauro Piacentini, Delia Goletti
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Immunology
Subjects:
cysteamine
tuberculosis
host-directed therapy
inflammation
Ag-specific response
PPD-specific response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1411827/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1411827/full

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