Structural basis of HIV-1 neutralization by affinity matured Fabs directed against the internal trimeric coiled-coil of gp41.

Structural basis of HIV-1 neutralization by affinity matured Fabs directed against the internal trimeric coiled-coil of gp41.

The conserved internal trimeric coiled-coil of the N-heptad repeat (N-HR) of HIV-1 gp41 is transiently exposed during the fusion process by forming a pre-hairpin intermediate, thus representing an attractive target for the design of fusion inhibitors and neutralizing antibodies. In previous studies...

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Bibliographic Details
Main Authors: Elena Gustchina, Mi Li, John M Louis, D Eric Anderson, John Lloyd, Christian Frisch, Carole A Bewley, Alla Gustchina, Alexander Wlodawer, G Marius Clore
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001182&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001182&type=printable

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