ERα-dependent crosstalk between macrophages and cancer cells potentiates vasculogenic mimicry and M2 macrophage polarization in bladder cancer

ERα-dependent crosstalk between macrophages and cancer cells potentiates vasculogenic mimicry and M2 macrophage polarization in bladder cancer

Abstract Gender related differences in the occurrence and progression of bladder cancer are affected by sex hormones and their receptor signaling pathways. Angiogenesis inhibitors targeting vascular endothelial growth factor do not show therapeutic effectiveness in bladder cancer patients. In this s...

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Bibliographic Details
Main Authors: Qing Liu, Jinpeng Wang, Shan Gao, Zhuolun Li, Wei Zhang, Weiyang Liu, Bingmei Liu, Guanglu Dong, Bosen You
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cell Communication and Signaling
Subjects:
Bladder cancer
ERα
Vascular mimicry
Polarization of M2 macrophage
Exosome
Online Access:https://doi.org/10.1186/s12964-025-02297-7
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https://doi.org/10.1186/s12964-025-02297-7

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