Suppression of human and rat 17β-hydroxysteroid dehydrogenase 1 by isothiazolinone-based disinfectants: Insights into mechanism and implications for hormonal homeostasis

Suppression of human and rat 17β-hydroxysteroid dehydrogenase 1 by isothiazolinone-based disinfectants: Insights into mechanism and implications for hormonal homeostasis

Isothiazolinone disinfectants constitute a class of broad-spectrum antimicrobial agents due to the pandemic of COVID-19. The aim of this study was to assess the impacts of six distinct isothiazolinone disinfectants on the activity of 17β-hydroxysteroid dehydrogenase 1 (17β-HSD1) in humans and rats,...

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Bibliographic Details
Main Authors: Chuhang Chi, Chaochao Gong, Yunbing Tang, He Zhu, Qian Zhang, Yang Zhu, Shaowei Wang, Ren-shan Ge, Xiaoheng Li
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Ecotoxicology and Environmental Safety
Subjects:
17β-HSD1
Estradiol
Isothiazolinone disinfectants
Docking analysis
3D-QSAR
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325005846
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