Individualized co-expression-like index (iCKI) enables gene–gene interactions as individual biomarkers for complex disease

Individualized co-expression-like index (iCKI) enables gene–gene interactions as individual biomarkers for complex disease

Abstract When a single gene exhibits an insignificant association with complex disease, applying gene–gene interactions as biomarkers may achieve striking findings. However, it is still a barrier to measuring the strength of gene–gene interaction at the individual level and further applying gene–gen...

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Main Authors: Chen Sun, Haiyan Chen, Jing Xu, Siyu Wei, Junxian Tao, Jiacheng Wang, Yuping Zou, Wei She, Ruilin Li, Linna Yuan, Fanwu Kong, Guoping Tang, Zhenwei Shang, Wenhua Lyu, Mingming Zhang, Hongchao Lyu, Yongshuai Jiang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Bioinformatics
Subjects:
Co-expression
Interaction
Individual
Index
Biomarker
Online Access:https://doi.org/10.1186/s12859-025-06225-x
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https://doi.org/10.1186/s12859-025-06225-x

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