Natural Antioxidants Reduce Oxidative Stress and the Toxic Effects of RNA-CUG<sub>(exp)</sub> in an Inducible Glial Myotonic Dystrophy Type 1 Cell Model

Natural Antioxidants Reduce Oxidative Stress and the Toxic Effects of RNA-CUG<sub>(exp)</sub> in an Inducible Glial Myotonic Dystrophy Type 1 Cell Model

The toxic gain-of-function of RNA-CUG<sub>(exp)</sub> in DM1 has been largely studied in skeletal muscle, with little focus on its effects on the central nervous system (CNS). This study aimed to study if oxidative stress is present in DM1, its relationship with the toxic RNA gain-of-fun...

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Bibliographic Details
Main Authors: Fernando Morales, Dayana Vargas, Melissa Palma-Jiménez, Esteban J. Rodríguez, Gabriela Azofeifa, Oscar Hernández-Hernández
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Antioxidants
Subjects:
myotonic dystrophy
RNA toxic gain-of-function
inducible model
glial cell model
antioxidants
treatment
Online Access:https://www.mdpi.com/2076-3921/14/3/260
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