Stem cell factor restrains endoplasmic reticulum stress-associated apoptosis through c-Kit receptor activation of JAK2/STAT3 axis in hippocampal neuronal cells.

Stem cell factor restrains endoplasmic reticulum stress-associated apoptosis through c-Kit receptor activation of JAK2/STAT3 axis in hippocampal neuronal cells.

<h4>Background</h4>Alzheimer's disease (AD) is a common elderly disorder characterized by cognitive decline. Endoplasmic reticulum (ER) stress has been implicated in various neurodegenerative diseases, including AD. Stem cell factor (SCF) performs its biological functions by binding...

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Main Authors: Haiying Shen, Junjie Nie, Guangqing Li, Hongyan Tian, Jun Zhang, Xiaofeng Luo, Da Xu, Jie Sun, Dongfang Zhang, Hong Zhang, Guifang Zhao, Weiyao Wang, Zhonghua Zheng, Shuyan Yang, Yuji Jin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0310872
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https://doi.org/10.1371/journal.pone.0310872

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