Neutrophil-Derived IL-6 Potentially Drives Ferroptosis Resistance in B Cells in Lupus Kidney
Ferroptosis resistance is vital for B cell development, especially in inflammatory diseases, yet the underlying mechanism is still unclear. In this study, based on the scRNA-seq technique and flow cytometry, we discovered a proportion of neutrophils exhibited upregulated expression of the IL-6 and c...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2023/9810733 |
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| _version_ | 1832547368512258048 |
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| author | Zechen Wang Jiajia Shen Kun Ye Jingjie Zhao Shaoang Huang Siyuan He Yujuan Qin Lingzhang Meng Jie Wang Jian Song |
| author_facet | Zechen Wang Jiajia Shen Kun Ye Jingjie Zhao Shaoang Huang Siyuan He Yujuan Qin Lingzhang Meng Jie Wang Jian Song |
| author_sort | Zechen Wang |
| collection | DOAJ |
| description | Ferroptosis resistance is vital for B cell development, especially in inflammatory diseases, yet the underlying mechanism is still unclear. In this study, based on the scRNA-seq technique and flow cytometry, we discovered a proportion of neutrophils exhibited upregulated expression of the IL-6 and correlated with the expression of IL-6 receptor and SLC7A11 from B cells in lupus kidney. Moreover, we identified that in lupus kidney, neutrophils could provide IL-6 to facilitate ferroptosis resistance in B cells via SLC7A11, and inhibition of SLC7A11 could significantly enhance ferroptosis in B cells and could decrease B cell proliferation. This study helps understand the crosstalk between neutrophils and B cells in the kidney in the development of lupus. |
| format | Article |
| id | doaj-art-7a33290212e741d4ba34a3cc939c010d |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7a33290212e741d4ba34a3cc939c010d2025-02-03T06:45:02ZengWileyMediators of Inflammation1466-18612023-01-01202310.1155/2023/9810733Neutrophil-Derived IL-6 Potentially Drives Ferroptosis Resistance in B Cells in Lupus KidneyZechen Wang0Jiajia Shen1Kun Ye2Jingjie Zhao3Shaoang Huang4Siyuan He5Yujuan Qin6Lingzhang Meng7Jie Wang8Jian Song9Center for Systemic Inflammation Research (CSIR)Center for Systemic Inflammation Research (CSIR)Department of Renal DiseasesLife Science and Clinical Research CenterCenter for Systemic Inflammation Research (CSIR)Center for Systemic Inflammation Research (CSIR)Center for Systemic Inflammation Research (CSIR)Center for Systemic Inflammation Research (CSIR)Center for Systemic Inflammation Research (CSIR)Center for Systemic Inflammation Research (CSIR)Ferroptosis resistance is vital for B cell development, especially in inflammatory diseases, yet the underlying mechanism is still unclear. In this study, based on the scRNA-seq technique and flow cytometry, we discovered a proportion of neutrophils exhibited upregulated expression of the IL-6 and correlated with the expression of IL-6 receptor and SLC7A11 from B cells in lupus kidney. Moreover, we identified that in lupus kidney, neutrophils could provide IL-6 to facilitate ferroptosis resistance in B cells via SLC7A11, and inhibition of SLC7A11 could significantly enhance ferroptosis in B cells and could decrease B cell proliferation. This study helps understand the crosstalk between neutrophils and B cells in the kidney in the development of lupus.http://dx.doi.org/10.1155/2023/9810733 |
| spellingShingle | Zechen Wang Jiajia Shen Kun Ye Jingjie Zhao Shaoang Huang Siyuan He Yujuan Qin Lingzhang Meng Jie Wang Jian Song Neutrophil-Derived IL-6 Potentially Drives Ferroptosis Resistance in B Cells in Lupus Kidney Mediators of Inflammation |
| title | Neutrophil-Derived IL-6 Potentially Drives Ferroptosis Resistance in B Cells in Lupus Kidney |
| title_full | Neutrophil-Derived IL-6 Potentially Drives Ferroptosis Resistance in B Cells in Lupus Kidney |
| title_fullStr | Neutrophil-Derived IL-6 Potentially Drives Ferroptosis Resistance in B Cells in Lupus Kidney |
| title_full_unstemmed | Neutrophil-Derived IL-6 Potentially Drives Ferroptosis Resistance in B Cells in Lupus Kidney |
| title_short | Neutrophil-Derived IL-6 Potentially Drives Ferroptosis Resistance in B Cells in Lupus Kidney |
| title_sort | neutrophil derived il 6 potentially drives ferroptosis resistance in b cells in lupus kidney |
| url | http://dx.doi.org/10.1155/2023/9810733 |
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