PKA regulation of neuronal function requires the dissociation of catalytic subunits from regulatory subunits

PKA regulation of neuronal function requires the dissociation of catalytic subunits from regulatory subunits

Protein kinase A (PKA) plays essential roles in diverse cellular functions. However, the spatiotemporal dynamics of endogenous PKA upon activation remain debated. The classical model predicts that PKA catalytic subunits dissociate from regulatory subunits in the presence of cAMP, whereas a second mo...

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Bibliographic Details
Main Authors: Weihong Xiong, Maozhen Qin, Haining Zhong
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-11-01
Series:eLife
Subjects:
cAMP-dependent kinase / protein kinase A (PKA)
two-photon imaging
norepinephrine
shRNA knockdown
late-phase structural long-term potentiation
AMPA and NMDA-mediated synaptic transmission
Online Access:https://elifesciences.org/articles/93766
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https://elifesciences.org/articles/93766

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