Cardiomyocyte Foxp1‐Specific Deletion Promotes Post‐injury Heart Regeneration via Targeting Usp20‐HIF1ɑ‐Hand1 Signaling Pathway

Cardiomyocyte Foxp1‐Specific Deletion Promotes Post‐injury Heart Regeneration via Targeting Usp20‐HIF1ɑ‐Hand1 Signaling Pathway

Abstract The adult mammalian heart has limited regenerative capacity to replace lost tissue after a major injury. Forkhead box P1 (Foxp1) regulates embryonic cardiomyocyte proliferation and heart development. However, whether Foxp1 participates in postnatal‐injury cardiomyocyte proliferation and hea...

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Bibliographic Details
Main Authors: Yanfang Wang, Xiaoyu Wang, Ji Fang, Xiaoli Chen, Teng Xu, Tao Zhuang, Sheng Peng, Wenzhen Bao, Wenrun Wu, Yushi Lu, Haikun Wang, Brian Tomlinson, Paul Chan, Shougang Zhuang, Qi Zhang, Lin Zhang, Zhongmin Liu, Jingjiang Pi, Yuzhen Zhang, Jie Liu
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
forkhead box P1
heart regenerations
metabolic transitions
myocardial infarctions
Online Access:https://doi.org/10.1002/advs.202412124
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https://doi.org/10.1002/advs.202412124

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