Cooperation between somatic mutation and germline-encoded residues enables antibody recognition of HIV-1 envelope glycans.

Cooperation between somatic mutation and germline-encoded residues enables antibody recognition of HIV-1 envelope glycans.

Viral glycoproteins are a primary target for host antibody responses. However, glycans on viral glycoproteins can hinder antibody recognition since they are self glycans derived from the host biosynthesis pathway. During natural HIV-1 infection, neutralizing antibodies are made against glycans on HI...

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Main Authors: Nelson R Wu, Nathan I Nicely, Esther M Lee, Rachel K Reed, Brian E Watts, Fangping Cai, William E Walkowicz, Baptiste Aussedat, Julia A Jones, Amanda Eaton, Ashley M Trama, S Munir Alam, David C Montefiori, Barton F Haynes, Kevin O Saunders
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-12-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1008165&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1008165&type=printable

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