ADAP and SKAP55 deficiency suppresses PD‐1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti‐tumor immunotherapy

ADAP and SKAP55 deficiency suppresses PD‐1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti‐tumor immunotherapy

Abstract PD‐1 negatively regulates CD8+ cytotoxic T lymphocytes (CTL) cytotoxicity and anti‐tumor immunity. However, it is not fully understood how PD‐1 expression on CD8+ CTL is regulated during anti‐tumor immunotherapy. In this study, we have identified that the ADAP‐SKAP55 signaling module reduce...

Full description

Saved in:
Bibliographic Details
Main Authors: Chunyang Li, Weiyun Li, Jun Xiao, Shaozhuo Jiao, Fei Teng, Shengjie Xue, Chi Zhang, Chun Sheng, Qibin Leng, Christopher E Rudd, Bin Wei, Hongyan Wang
Format: Article
Language:English
Published: Springer Nature 2015-04-01
Series:EMBO Molecular Medicine
Subjects:
ADAP/SKAP55
anti‐tumor immunotherapy
CsA
CTL cytotoxicity
PD‐1
Online Access:https://doi.org/10.15252/emmm.201404578
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.15252/emmm.201404578

Similar Items