OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination

OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination

Abstract Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that reversible ubiquitination of RAS GTPases dramatically affects their activity, suggesting that enzymes involved in regulating RAS ubiqui...

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Bibliographic Details
Main Authors: Maria Francesca Baietti, Michal Simicek, Layka Abbasi Asbagh, Enrico Radaelli, Sam Lievens, Jonathan Crowther, Mikhail Steklov, Vasily N Aushev, David Martínez García, Jan Tavernier, Anna A Sablina
Format: Article
Language:English
Published: Springer Nature 2016-02-01
Series:EMBO Molecular Medicine
Subjects:
lung cancer
RAS
reversible ubiquitination
Online Access:https://doi.org/10.15252/emmm.201505972
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https://doi.org/10.15252/emmm.201505972

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