Construction of Minigenome Replicon of Nipah Virus and Investigation of Biological Activity

Construction of Minigenome Replicon of Nipah Virus and Investigation of Biological Activity

Nipah virus (NiV), a highly lethal zoonotic pathogen causing encephalitis and respiratory diseases with mortality rates up to 40–70%, faces research limitations due to its strict biosafety level 4 (BSL-4) containment requirements, hindering antiviral development. To address this, we generated two Ni...

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Bibliographic Details
Main Authors: Fan Wang, Ruyi Chen, Jiayi Zhong, Anqi Zhou, Ran Peng, Bao Xue, Yuan Zhou, Jielin Tang, Xinwen Chen, Qi Yang
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Viruses
Subjects:
Nipah virus (NiV)
minigenome replicon
inclusion bodies (IBs)
antivirals
Online Access:https://www.mdpi.com/1999-4915/17/5/707
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