Structure activity relationships of antischistosomal N-phenylbenzamides by incorporation of electron-withdrawing functionalities

Structure activity relationships of antischistosomal N-phenylbenzamides by incorporation of electron-withdrawing functionalities

For the adult Schistosoma mansoni flatworm pathogen, we report further structure activity relationships (SAR) of 19 N-phenylbenzamide analogs. Our previous SAR studies, designed by selecting representative substituents from the Craig plot, identified 9 and 11 which possessed electron-withdrawing gro...

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Main Authors: Ameera Mohammed Dawoodjee, John Sichinga, Harrison Banda, Steve Mbaya, Evelyn Funjika, Godfrey Mayoka, Christabel Hikaambo, Karol R. Francisco, Yujie Uli Sun, Lawrence J. Liu, Conor R. Caffrey, Peter Mubanga Cheuka
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Results in Chemistry
Subjects:
N-phenylbenzamide analogs
N-pyridazinylbenzamide analogs
Schistosoma mansoni
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715624005861
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