Excessive exercise elicits poly (ADP-ribose) Polymerase-1 activation and global protein PARylation driving muscle dysfunction and performance impairment

Excessive exercise elicits poly (ADP-ribose) Polymerase-1 activation and global protein PARylation driving muscle dysfunction and performance impairment

Excessive exercise combined with inadequate recovery time may trigger fatigue, performance impairment, and ultimately the overtraining syndrome. The intramyocellular mechanisms involved in the overtraining syndrome remain only partially known. Here, we combined multi-omics analyses from isogenic BXD...

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Main Authors: Barbara M. Crisol, Matheus B. Rocha, Beatriz Franco, Ana Paula Morelli, Carlos K. Katashima, Scylas J.A. Junior, Fernanda S. Carneiro, Renata R. Braga, Rafael S. Brícola, Graciana de Azambuja, Raul Gobato Costa, Andrea M. Esteves, Marcelo A. Mori, Maria C.G. Oliveira, Dennys E. Cintra, José R. Pauli, Filip J. Larsen, Adelino S.R. da Silva, Eduardo R. Ropelle
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Metabolism
Subjects:
Exercise
Muscle
PARP1
overtraining
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000420
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