Biomimetic Nanoplatform for Targeted Rheumatoid Arthritis Therapy: Modulating Macrophage Niches Through Self‐Sustaining Positive Feedback‐Driven Drug Release Mechanisms

Biomimetic Nanoplatform for Targeted Rheumatoid Arthritis Therapy: Modulating Macrophage Niches Through Self‐Sustaining Positive Feedback‐Driven Drug Release Mechanisms

Abstract The core strategies in treating rheumatoid arthritis (RA) now focus on ameliorating the inflammatory microenvironment and reversing macrophage phenotypes within the joint cavity. This study introduces a co‐delivery system of integrating nanoenzymes and gene therapeutics sequentially modifie...

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Main Authors: Huichao Xie, Xiaoyu Huang, Bao Li, Yongfeng Chen, Haoran Niu, Tong Yu, Shimei Yang, Shuxin Gao, Yutong Zeng, Tianzhi Yang, Yan Kang, Keda Zhang, Pingtian Ding
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
biomimetic nanodelivery platform
gene silencing
guanidinium‐based polymers
prussian blue nanoenzymes
rheumatoid arthritis
Online Access:https://doi.org/10.1002/advs.202416265
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https://doi.org/10.1002/advs.202416265

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