ATXN3 deubiquitinates ZEB1 and facilitates epithelial–mesenchymal transition in glioblastoma

ATXN3 deubiquitinates ZEB1 and facilitates epithelial–mesenchymal transition in glioblastoma

Abstract The activation of epithelial–mesenchymal transition (EMT) promotes glioblastoma (GBM) invasion, thereby enhancing its malignancy. Elucidating the underlying mechanisms that regulate EMT is essential for the development of effective treatments for GBM. In this study, we found that GBM tissue...

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Bibliographic Details
Main Authors: Ruting Wei, Xueping Shi, Wenjin Qiu, Ming Yang, Yimin Chen, Shibin Song, Hua Yang, Jian Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Glioblastoma
Invasion
Migration
Deubiquitination
Protein degradation
Online Access:https://doi.org/10.1038/s41598-025-92317-w
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https://doi.org/10.1038/s41598-025-92317-w

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