The novel amino-artemisinin derivative WHN-11 disrupts mitochondria and protein homeostasis, and induces autophagy and apoptosis in cancer cells

The novel amino-artemisinin derivative WHN-11 disrupts mitochondria and protein homeostasis, and induces autophagy and apoptosis in cancer cells

Abstract Semi-synthetic derivatives of artemisinin exhibit anti-cancer activity in vitro and in vivo in addition to anti-malarial activity. Here, we report the anti-cancer and anti-cancer stem cell potential of novel C-10 substituted amino-artemisinin derivatives. Of these, the 4’-trifluoromethylary...

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Bibliographic Details
Main Authors: Deborah Kajewole, Ho Ning Wong, Alexander von Kriegsheim, Richard K. Haynes, Jo-Anne de la Mare, Adrienne Lesley Edkins
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Amino-artemisinin
Triple-negative breast cancer (TNBC)
Reactive oxygen species (ROS)
Apoptosis
Autophagy
Mitochondrial fission
Online Access:https://doi.org/10.1038/s41598-025-05284-7
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https://doi.org/10.1038/s41598-025-05284-7

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