HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway

HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway

Abstract Background Hepatic inflammation is a common initiator of liver diseases and considered as the primary driver of hepatocellular carcinoma (HCC). However, the precise mechanism of inflammation-induced HCC development and immune evasion remains elusive and requires extensive investigation. Thi...

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Main Authors: Yunzhi Liu, Qishan Xu, Fan Deng, Zhuojun Zheng, Jialiang Luo, Ping Wang, Jia Zhou, Xiao Lu, Liyun Zhang, Zhengliang Chen, Qifan Zhang, Qingyun Chen, Daming Zuo
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
HERC2
Hepatocellular carcinoma
JAK2/STAT3 signaling
Cancer stemness
PD-L1
Online Access:https://doi.org/10.1186/s13046-023-02609-0
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https://doi.org/10.1186/s13046-023-02609-0

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