Macrophage-augmented intestinal organoids model virus-host interactions in enteric viral diseases and facilitate therapeutic development

Macrophage-augmented intestinal organoids model virus-host interactions in enteric viral diseases and facilitate therapeutic development

Abstract The pathogenesis of enteric viral infections is attributed to both viral replication and the resultant immune-inflammatory response. To recapitulate this complex pathophysiology, we engineer macrophage-augmented organoids (MaugOs) by integrating human macrophages into primary intestinal org...

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Main Authors: Guige Xu, Jiangrong Zhou, Kuan Liu, Yining Wang, Theano Tsikari, Fang Qin, Francijna van den Hil, Patrick P. C. Boor, Ibrahim Ayada, Annemarie C. de Vries, Jiajing Li, Shijin Jiang, Dewy M. Offermans, Denis E. Kainov, Harry L. A. Janssen, Maikel P. Peppelenbosch, Marcel J. C. Bijvelds, Wenshi Wang, Valeria V. Orlova, Qiuwei Pan, Pengfei Li
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59639-9
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https://doi.org/10.1038/s41467-025-59639-9

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