NT157 exhibits antineoplastic effects by targeting IRS and STAT3/5 signaling in multiple myeloma

NT157 exhibits antineoplastic effects by targeting IRS and STAT3/5 signaling in multiple myeloma

Multiple myeloma (MM) is a prevalent hematological malignancy with high recurrence and no definitive cure. The current study revisits the role of the IGF1/IGF1R axis in MM, introducing a novel inhibitor, NT157. The IGF1/IGF1R pathway is pivotal in MM, influencing cell survival, proliferation, and mi...

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Bibliographic Details
Main Authors: Gustavo Nery de Queiroz, Keli Lima, Livia Bassani Lins de Miranda, Eduardo Magalhães Rego, Fabiola Traina, João Agostinho Machado-Neto
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Hematology, Transfusion and Cell Therapy
Subjects:
Multiple myeloma
IGF1/IGF1R axis
NT157
Hematological malignancy
Tumor suppression
Online Access:http://www.sciencedirect.com/science/article/pii/S2531137924000622
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http://www.sciencedirect.com/science/article/pii/S2531137924000622

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