Signaling through the nicotinic acetylcholine receptor in the liver protects against the development of metabolic dysfunction-associated steatohepatitis.

Signaling through the nicotinic acetylcholine receptor in the liver protects against the development of metabolic dysfunction-associated steatohepatitis.

Metabolic dysfunction-associated steatohepatitis (MASH) is the progressive form of liver steatosis, the most common liver disease, and substantially increases the mortality rate. However, limited therapies are currently available to prevent MASH development. Identifying potential pharmacological tre...

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Main Authors: Heejin Jun, Shanshan Liu, Alexander J Knights, Kezhou Zhu, Yingxu Ma, Jianke Gong, Ashley E Lenhart, Xiaoling Peng, Yunying Huang, Jared P Ginder, Christopher H Downie, Erika Thalia Ramos, Klas Kullander, Robert T Kennedy, X Z Shawn Xu, Jun Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-07-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002728
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https://doi.org/10.1371/journal.pbio.3002728

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