Optimizing ibrutinib bioavailability: Formulation and assessment of hydroxypropyl-β-cyclodextrin-based nanosponge delivery systems

Optimizing ibrutinib bioavailability: Formulation and assessment of hydroxypropyl-β-cyclodextrin-based nanosponge delivery systems

Background: The current research aims to improve the oral bioavailability of ibrutinib (IBR), a class II drug with low solubility, through the formulation of nanosponges (NSPs) that incorporate IBR, utilizing Hydroxypropyl β-cyclodextrin (HPβCD) and 1,1′-carbonyldiimidazole (CDI) as cross-linking ag...

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Bibliographic Details
Main Authors: Sunitha Sampathi, Nitiraj Kulkarni, D.V.R.N. Bhikshapathi, Jagadish V. Tawade, Nainaru Tarakaramu, Rzgar Farooq Rashid, Aziz Kubaev
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Current Research in Pharmacology and Drug Discovery
Subjects:
Cross-linker
1,1′-carbonyldiimidazole
Hydroxypropyl β-cyclodextrin
Ibrutinib
Sustained release
QbD
Online Access:http://www.sciencedirect.com/science/article/pii/S259025712500001X
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http://www.sciencedirect.com/science/article/pii/S259025712500001X

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