Neuromodulation of voltage-gated sodium channels by Gβ1γ2 subunits: Implications for GNB1-linked encephalopathy

Neuromodulation of voltage-gated sodium channels by Gβ1γ2 subunits: Implications for GNB1-linked encephalopathy

Summary: Guanine nucleotide-binding protein Gβγ subunits are ubiquitous signaling molecules that interact with numerous effector proteins in neurons, including voltage-gated sodium, calcium, and potassium channels. We show that Gβγ subunits associate with voltage-gated sodium channels (Navs) in mous...

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Bibliographic Details
Main Authors: Nicholas Denomme, Samantha L. Hodges, Luis Lopez-Santiago, Yukun Yuan, Julie M. Ziobro, Joe Minton, Chunling Chen, Yan Chen, Jacob M. Hull, James Offord, Alan V. Smrcka, Lori L. Isom
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neurobiology of Disease
Subjects:
Voltage-gated sodium channel
G-protein
GNB1
Developmental and epileptic encephalopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002062
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