Psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis

Psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis

Ovarian tumor (OT) is the most lethal form of gynecologic malignancy, with minimal improvements in patient outcomes over the past several decades. Metastasis is the leading cause of ovarian cancer-related deaths, yet the underlying mechanisms remain poorly understood. Psychological stress is known t...

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Bibliographic Details
Main Authors: Bin Liu, Wen-Zhe Deng, Wen-Hua Hu, Rong-Xi Lu, Qing-Yu Zhang, Chen-Feng Gao, Xiao-Jie Huang, Wei-Guo Liao, Jin Gao, Yang Liu, Hiroshi Kurihara, Yi-Fang Li, Xu-Hui Zhang, Yan-Ping Wu, Lei Liang, Rong-Rong He
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
NR3C1
NUPR1
Ovarian tumor
EMT
Prognostic biomarker
Psychological stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525002187
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