Decoding diabetic kidney disease: a comprehensive review of interconnected pathways, molecular mediators, and therapeutic insights

Decoding diabetic kidney disease: a comprehensive review of interconnected pathways, molecular mediators, and therapeutic insights

Abstract Background Diabetic kidney disease (DKD) is a chronic kidney condition that arises from prolonged hyperglycaemia that can progress to kidney failure, severe morbidity, and mortality if left untreated. It is the major cause of chronic kidney disease among people who have diabetes, accounting...

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Main Authors: Esienanwan Esien Efiong, Kathrin Maedler, Emmanuel Effa, Uchechukwu Levi Osuagwu, Esther Peters, Joshua Onyeka Ikebiuro, Chisom Soremekun, Ugwunna Ihediwa, Jiefei Niu, Markéta Fuchs, Homa Bazireh, Akang Leonard Bassey, Peter Uchenna Amadi, Qiuling Dong, Njogu Mark Kimani, Rebecca Chinyelu Chukwuanukwu, Emmy Tuenter, Sapna Sharma, Harald Grallert
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Diabetic nephropathy
Signal pathways
Chronic kidney disease
End-stage kidney disease
Renin–angiotensin–aldosterone system
Toll-like receptors
Online Access:https://doi.org/10.1186/s13098-025-01726-4
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https://doi.org/10.1186/s13098-025-01726-4

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