In silico characterization of the interaction of AKR1B1 with the deacetylase activation domain (DAD)

In silico characterization of the interaction of AKR1B1 with the deacetylase activation domain (DAD)

The aldo-keto reductase family 1 member B1 (AKR1B1) plays a key role in cancer progression by competing with histone deacetylase 3 to bind to the deacetylase activation domain (DAD) of the nuclear receptor corepressor SMRT. Previous studies showed that the L289A mutation in AKR1B1 disrupts its abili...

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Bibliographic Details
Main Authors: Francisco J. Gómez-Zaldívar, Luis Córdova-Bahena, Angel J. Ruiz-Moreno, Paolo Ceppi, Marco A. Velasco-Velázquez
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
AKR1B1
deacetylase activation domain
nuclear receptor corepressor
molecular dynamics
binding sites prediction
protein-protein interaction
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1562206/full
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https://www.frontiersin.org/articles/10.3389/fmolb.2025.1562206/full

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