The pathogenesis and therapeutic implications of metabolic reprogramming in renal cell carcinoma

Abstract Renal cell carcinoma (RCC), a therapeutically recalcitrant genitourinary malignancy, exemplifies the profound interplay between oncogenic signaling and metabolic adaptation. Emerging evidence positions metabolic reprogramming as a central axis of RCC pathogenesis, characterized by dynamic s...

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Bibliographic Details
Main Authors: Yifan Zhang, Shengli Zhang, Hongbin Sun, Luwei Xu
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02479-9
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