New insight into Alzheimer's disease: Light reverses Aβ‐obstructed interstitial fluid flow and ameliorates memory decline in APP/PS1 mice

New insight into Alzheimer's disease: Light reverses Aβ‐obstructed interstitial fluid flow and ameliorates memory decline in APP/PS1 mice

Abstract Introduction Pharmacological therapies to treat Alzheimer's disease (AD) targeting “Aβ” have failed for over 100 years. Low levels of laser light can disassemble Aβ. In this study, we investigated the mechanisms that Aβ‐blocked extracellular space (ECS) induces memory disorders in APP/...

Full description

Saved in:
Bibliographic Details
Main Authors: Xiangpei Yue, Yufei Mei, Yun Zhang, Zheng Tong, Dehua Cui, Jun Yang, Aibo Wang, Rui Wang, Xuechao Fei, Li Ai, Yalan Di, Hongjun Luo, Hui Li, Wenhong Luo, Yu Lu, Rui Li, Chunli Duan, Ge Gao, Hui Yang, Binggui Sun, Rongqiao He, Weihong Song, Hongbin Han, Zhiqian Tong
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
Red light (RL)
Alzheimer's disease (AD)
Amyloid β (Aβ)
Formaldehyde (FA)
Formaldehyde dehydrogenase (FDH)
Extracellular space (ECS)
Online Access:https://doi.org/10.1016/j.trci.2019.09.007
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1016/j.trci.2019.09.007

Similar Items