Discovery and Characterisation of Novel Poly-Histidine-Poly-Glycine Peptides as Matrix Metalloproteinase Inhibitors

Discovery and Characterisation of Novel Poly-Histidine-Poly-Glycine Peptides as Matrix Metalloproteinase Inhibitors

For the first time, two poly-histidine-poly-glycine peptides (pHpG-H5 and pHpG-H7) were identified as promising candidates for matrix metalloproteinase inhibitors. cDNAs encoding pHpG-H5 and pHpG-H7 peptides were isolated from the <i>Atheris squamigera</i> cDNA library constructed using...

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Bibliographic Details
Main Authors: He Wang, Wenchao Cai, Zhiyu Tang, Juanli Fu, Enrico König, Nanwen Zhang, Xiaole Chen, Tianbao Chen, Chris Shaw
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomolecules
Subjects:
snake venom
molecular cloning
matrix metalloproteinases
peptide inhibitor
Online Access:https://www.mdpi.com/2218-273X/15/5/706
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