Precise Correction of Lhcgr Mutation in Stem Leydig Cells by Prime Editing Rescues Hereditary Primary Hypogonadism in Mice

Precise Correction of Lhcgr Mutation in Stem Leydig Cells by Prime Editing Rescues Hereditary Primary Hypogonadism in Mice

Abstract Hereditary primary hypogonadism (HPH), caused by gene mutation related to testosterone synthesis in Leydig cells, usually impairs male sexual development and spermatogenesis. Genetically corrected stem Leydig cells (SLCs) transplantation may provide a new approach for treating HPH. Here, a...

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Main Authors: Kai Xia, Fulin Wang, Zhipeng Tan, Suyuan Zhang, Xingqiang Lai, Wangsheng Ou, Cuifeng Yang, Hong Chen, Hao Peng, Peng Luo, Anqi Hu, Xiang'an Tu, Tao Wang, Qiong Ke, Chunhua Deng, Andy Peng Xiang
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Advanced Science
Subjects:
hypogonadism
prime editing
spermatogenesis
stem Leydig cells
testis
testosterone
Online Access:https://doi.org/10.1002/advs.202300993
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https://doi.org/10.1002/advs.202300993

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