Identifying prioritization of therapeutic targets for ankylosing spondylitis: a multi-omics Mendelian randomization study

Identifying prioritization of therapeutic targets for ankylosing spondylitis: a multi-omics Mendelian randomization study

Abstract Background To investigate the associations of methylation, expression, and protein quantitative trait loci (mQTL, eQTL, and pQTL) with ankylosing spondylitis (AS) and find out genetically supported drug targets for AS. Methods The summary-data-based Mendelian randomization (SMR) and Bayesia...

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Bibliographic Details
Main Authors: Lingyu Dai, Lan Xia, Guannan Su, Yu Gao, Qingyan Jiang, Peizeng Yang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Translational Medicine
Subjects:
Ankylosing spondylitis
Mendelian randomization
Multi-omics
Methylation
Gene expression
Protein
Online Access:https://doi.org/10.1186/s12967-024-05925-x
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https://doi.org/10.1186/s12967-024-05925-x

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