Multi-omics integration and machine learning uncover molecular basal-like subtype of pancreatic cancer and implicate A2ML1 in promoting tumor epithelial-mesenchymal transition

Multi-omics integration and machine learning uncover molecular basal-like subtype of pancreatic cancer and implicate A2ML1 in promoting tumor epithelial-mesenchymal transition

Abstract Background Pancreatic cancer (PC) represents a highly heterogeneous malignancy with poor prognosis, where precise molecular subtyping facilitates comprehensive understanding of disease progression. Methods Transcriptomic, methylation, and mutational data from 168 PC samples were integrated....

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Bibliographic Details
Main Authors: Jiachen Ge, Jianping Cai, Gaolei Zhang, Deyu Li, Lianyuan Tao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Pancreatic cancer
Molecular subtype
Machine learning
Epithelial-mesenchymal transition
KRAS/MAPK pathway
Online Access:https://doi.org/10.1186/s12967-025-06711-z
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