Multi-omics integration and machine learning uncover molecular basal-like subtype of pancreatic cancer and implicate A2ML1 in promoting tumor epithelial-mesenchymal transition

Multi-omics integration and machine learning uncover molecular basal-like subtype of pancreatic cancer and implicate A2ML1 in promoting tumor epithelial-mesenchymal transition

Abstract Background Pancreatic cancer (PC) represents a highly heterogeneous malignancy with poor prognosis, where precise molecular subtyping facilitates comprehensive understanding of disease progression. Methods Transcriptomic, methylation, and mutational data from 168 PC samples were integrated....

Full description

Saved in:
Bibliographic Details
Main Authors: Jiachen Ge, Jianping Cai, Gaolei Zhang, Deyu Li, Lianyuan Tao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Pancreatic cancer
Molecular subtype
Machine learning
Epithelial-mesenchymal transition
KRAS/MAPK pathway
Online Access:https://doi.org/10.1186/s12967-025-06711-z
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12967-025-06711-z

Similar Items