SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL

SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL

Summary: Protein SUMOylation is crucial in both physiological and pathological contexts, but its role in acute liver injury (ALI) is poorly understood. We found that SENP3, a SUMO2/3 protease, rapidly accumulates in hepatocytes around the pericentral vein zone within 2 h of carbon tetrachloride (CCl...

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Main Authors: Xinyuan Xiong, Yang Zhi, Nan Yang, Wenzhen Zhao, Shu Wang, Huiqin Zhu, Jieting Tang, Jing Yi, Xuxu Sun, Jie Yang
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Molecular mechanism of gene regulation
Molecular network
Integrative aspects of cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225013288
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