eIF3a function in immunity and protection against severe sepsis by regulating B cell quantity and function through m6A modification

eIF3a function in immunity and protection against severe sepsis by regulating B cell quantity and function through m6A modification

eIF3a is a N6-methyladenosine (m6A) reader that regulates mRNA translation by recognizing m6A modifications of these mRNAs. It has been suggested that eIF3a may play an important role in regulating translation initiation via m6A during infection when canonical cap-dependent initiation is inhibited....

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Bibliographic Details
Main Authors: Qianying Ouyang, Jiajia Cui, Yang Wang, Ke Liu, Yan Zhan, Wei Zhuo, Juan Chen, Honghao Zhou, Chenhui Luo, Jianming Xia, Liansheng Wang, Chengxian Guo, Jianting Zhang, Zhaoqian Liu, Jiye Yin
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
eIF3a
m6A
Sepsis
B cell
RNA modification
Infection
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525000383
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