Design and Synthesis of Small Molecule Probes of MDA-9/Syntenin

Design and Synthesis of Small Molecule Probes of MDA-9/Syntenin

MDA-9/Syntenin, a key scaffolding protein and a molecular hub involved in a diverse range of cell signaling responses, has proved to be a challenging target for the design and discovery of small molecule probes. In this paper, we report on the design and synthesis of small molecule ligands of this k...

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Bibliographic Details
Main Authors: Nehru Viji Sankaranarayanan, Bharath Kumar Villuri, Balaji Nagarajan, Sarah Lewicki, Swadesh K. Das, Paul B. Fisher, Umesh R. Desai
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Biomolecules
Subjects:
anti-cancer agents
molecular modeling
PDZ domain
protein–protein interactions
small molecule inhibitors
Online Access:https://www.mdpi.com/2218-273X/14/10/1287
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